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Selective Structure-Based Virtual Screening for Full and Partial Agonists of the β2 Adrenergic Receptor

JOURNAL OF MEDICINAL CHEMISTRY, no. 16 (2008): 4978-4985

Cited: 144|Views28
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The recently solved high-resolution X-ray structure of the beta 2 adrenergic receptor has been challenged for its ability to discriminate inverse agonists/antagonists from partial/full agonists. Whereas the X-ray structure of the ground state receptor was unsuitable to distinguish true ligands with different functional effects, modifying ...More

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