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Solution Structure Of Microtubule-Associated Protein Light Chain 3 And Identification Of Its Functional Subdomains

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 26 (2005): 24610-24617

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Microtubule-associated protein ( MAP) light chain 3 (LC3) is a human homologue of yeast Apg8/Aut7/Cvt5 (Atg8), which is essential for autophagy. MAP-LC3 is cleaved by a cysteine protease to produce LC3-I, which is located in cytosolic fraction. LC3-I, in turn, is converted to LC3-II through the actions of E1- and E2-like enzymes. LC3-II i...更多

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