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The Human Taz Gene Complements Mitochondrial Dysfunction In The Yeast Taz1 Delta Mutant - Implications For Barth Syndrome

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 43 (2004): 44394-44399

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Abstract

Barth syndrome is a genetic disorder that is caused by different mutations in the TAZ gene G4.5. The yeast gene TAZ1 is highly homologous to human TAZ, and the taz1Delta mutant has phospholipid defects similar to those observed in Barth syndrome cells, including aberrant cardiolipin species and decreased cardiolipin levels. Subcellular fr...More

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