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The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells

JOURNAL OF CELL SCIENCE, no. 23 (2006): 4857.0-4865

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It has recently been suggested that the Saccharomyces cerevisiae protein ChI1p plays a role in cohesion establishment. Here, we show that the human ATP-dependent DNA helicase ChIR1 is required for sister chromatid cohesion in mammalian cells. Localization studies show that ChIR1 diffusely coats mitotic chromatin in prophase and then trans...更多

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