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Molecular alterations in spontaneous sputum of cancer-free heavy smokers: results from a large screening program.

Clinical cancer research : an official journal of the American Association for Cancer Research, no. 6 (2008): 1913-1919

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The high mortality rate for lung cancer is likely to be reduced by the development of a panel of sensitive biological markers able to identify early-stage lung cancers or subjects at high risk. The aim of this study was to establish the frequency of K-ras and p53 mutations and p16(INK4A), RASSF1A, and NORE1A hypermethylation in sputum of ...更多

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