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Unphosphorylated Stat3 Accumulates In Response To Il-6 And Activates Transcription By Binding To Nf Kappa B

GENES & DEVELOPMENT, no. 11 (2007): 1396-1408

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gp130-linked cytokines such as interleukin- 6 (IL-6) stimulate the formation of tyrosine-phosphorylated signal transducer and activator of transcription 3 (P- STAT3), which activates many genes, including the STAT3 gene itself. The resulting increase in the concentration of unphosphorylated STAT3 (U- STAT3) drives a second wave of express...更多

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