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Castration-Induced Apoptosis Of Androgen-Dependent Shionogi Carcinoma Is Associated With Increased Expression Of Genes Encoding Insulin-Like Growth Factor-Binding Proteins

CANCER RESEARCH, no. 14 (1999): 3392-3395

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Insulin-like growth factor (IGF) I has well-characterized mitogenic and antiapoptotic effects that are essential for maintenance of the normal prostate and may be important during regression of the normal prostate andlor prostate tumors induced by androgen-targeting therapies for prostate cancer. IGF-1 activity is modulated by IGF-bindlng...More

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