Low Micromolar Zinc Accelerates The Fibrillization Of Human Tau Via Bridging Of Cys-291 And Cys-322

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 50 (2009): 34648-34657

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A hallmark of a group of neurodegenerative diseases such as Alzheimer disease is the formation of neurofibrillary tangles, which are principally composed of bundles of filaments formed by microtubule-associated protein Tau. Clarifying how natively unstructured Tau protein forms abnormal aggregates is of central importance for elucidating ...更多

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