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Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular Disease

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, no. 11 (2008): 2150-2158

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academic.microsoft.com pubmed.ncbi.nlm.nih.gov

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MicroRNAs (miRNAs) regulate gene expression by binding the 3' untranslated region of mRNAs. To define their role in glomerular function, miRNA biogenesis was disrupted in mouse podocytes using a conditional Dicer allele. Mutant mice developed proteinuria by 3 wk after birth and progressed rapidly to end-stage kidney disease. Podocyte path...更多

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