Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.

Pengcheng P Shao,Feng Ye,Ann E Weber,Xiaohua Li,Kathryn A Lyons,William H Parsons,Maria L Garcia,Birgit T Priest,McHardy M Smith,John P Felix,Brande S Williams,Gregory J Kaczorowski,Erin McGowan,Catherine Abbadie,William J Martin,Daniel R McMasters,Ying-Duo Gao

Bioorganic & Medicinal Chemistry Letters（2009）

引用 19|浏览38

暂无评分

摘要

Analogs of the previously reported voltage gated sodium channel blocker CDA54 were prepared in which one of the amide functions was replaced with aromatic and non-aromatic heterocycles. Replacement of the amide with an aromatic heterocycle resulted in significant loss of sodium channel blocking activity, while non-aromatic heterocycle replacements were well tolerated.

查看译文

关键词

Voltage gated sodium channel blocker,Neuropathic pain,Inflammatory pain,Amide replacement,Heterocycles,Isoxazoline

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要