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Peripheral Tolerance of CD8 T Lymphocytes
Immunity, no. 3 (2005): 275-284
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摘要
Whereas high-avidity recognition of peptide-MHC complexes by developing T cells in the thymus results in deletion and promotes self-tolerance, such recognition by mature T cells in the periphery results in activation and clonal expansion. This dichotomy represents the basis of a dilemma that has stumped immunologists for many years, how a...更多
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