Granulocyte Colony-Stimulating Factor???Responsive Chronic Neutropenia in Cartilage???Hair Hypoplasia:

Chronic neutropenia is common in children with cartilage hair hypoplasia (CHH). The authors describe a 6-year-old with severe CHH, moderate neutropenia associated with serum IgG antibodies directed against Fcgamma-RIIIb (NA 1/2), and frequent bacterial infections. In this patient, long-term administration of granulocyte colony-stimulating factor increased peripheral neutrophil counts and prevented recurrent hospitalizations for bacterial lower respiratory tract infections.