Crystal Structure of the DNA Binding Domain of the Replication Initiation Protein E1 from Papillomavirus

Papillomaviral infection causes both benign and malignant lesions and is a necessary cause of cervical carcinoma. Replication of this virus requires the replication initiation proteins E1 and E2, which bind cooperatively at the origin of replication (ori) as an (E1)(2)-(E-2)(2)-DNA complex. This is a precursor to larger E1 complexes that ...更多