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On the mechanism of impaired insulin secretion in chronic renal failure.

JOURNAL OF CLINICAL INVESTIGATION, no. 1 (1991): 255-261

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It has been suggested that a sustained rise in resting levels of cytosolic calcium [Ca2+]i of pancreatic islets is responsible for impaired insulin secretion in chronic renal failure (CRF). Evidence for such an event is lacking and the mechanisms through which it may affect insulin secretion are not known. Studies were conducted in normal...更多

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