Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis

JOURNAL OF CELL BIOLOGY, no. 2 (2004): 303-313

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Despite the potential of the inhibitor of apoptosis proteins (IAPs) to block cytochrome c-dependent caspase activation, the critical function of IAPs in regulating mammalian apoptosis remains unclear. We report that the ability of endogenous IAPs to effectively regulate caspase activation depends on the differentiation state of the cell. ...更多

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