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Cd95 Signaling Via Ceramide-Rich Membrane Rafts

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 23 (2001): 20589-20596

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Clustering seems to be employed by many receptors for transmembrane signaling. Here, we show that acid sphingomyelinase (ASM)-released ceramide is essential for clustering of CD95, In vitro and in vivo, extracellularly orientated ceramide, released upon CD95-triggered translocation of ASM to the plasma membrane outer surface, enabled clus...更多

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