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Antigenic and functional characterization of a rat central nervous system-derived cell line immortalized by a retroviral vector

JOURNAL OF CELL BIOLOGY, no. 5 (1988): 1977-1986

Cited: 73|Views22
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Abstract

We have immortalized rat central nervous system (CNS) cells of primary cultures of rat optic nerve with murine leukemia virus w2,SV-40-6, which is defective in assembly and contains the SV-40 large T antigen and neomycin resistance genes, to produce a cell line that we named A7. After drug selection, >90% of the growing cells expressed nu...More

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