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Samarium-153-EDTMP: pharmacokinetic, toxicity and pain response using an escalating dose schedule in treatment of metastatic bone cancer.

JOURNAL OF NUCLEAR MEDICINE, no. 8 (1992): 1451-1458

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Abstract

Samarium-153 emits medium-energy beta particles and an imageable gamma photon with a physical half-life of 46.3 hr. When chelated to ethylenediaminetetramethylenephosphonic acid (EDTMP), it is remarkably stable in vitro and in vivo. In this study, we administered escalating amounts of Sm-153-EDTMP, from 0.1 to 1.0 mCi/kg (3.7-37 MBq/kg), ...More

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