Discovery Of Biologically-Active Peptides In Random Libraries - Solution-Phase Testing After Staged Orthogonal Release From Resin Beads

To speed drug discovery, we developed an approach for identification of individual peptides with a desired biological activity from a library containing millions of peptides. The approach uses sequential orthogonal release of chemically synthesized peptides from insoluble beads, followed by testing in solution. In this system, each bead w...更多