HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir.
JOURNAL OF CLINICAL INVESTIGATION, no. 11 (2006): 3250-3255
The persistence of latently infected, resting CD4(+) T cells is considered to be a major obstacle in preventing the eradication of HIV-1 even in patients who have received effective antiviral therapy for an average duration of 5 years. Although previous studies have suggested that the latent HIV reservoir in the resting CD4+ T cell compar...更多
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