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Treatment Of Myelodysplastic Syndromes With Valproic Acid Alone Or In Combination With All-Trans Retinoic Acid
BLOOD, no. 5 (2004): 1266-1269
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摘要
Valproic acid (VPA) has been shown to inhibit histone deacetylase activity and to synergize with all-trans retinoic acid (ATRA) in the differentiation induction of acute myelogenous leukemia (AML) blasts in vitro. We treated 18 patients with myelodysplastic syndromes (MDS) and AML secondary to MDS (sAML/MDS) with VPA monotherapy (serum co...更多
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