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P21(Cip1/Waf1) Disrupts The Recruitment Of Human Fen1 By Proliferating-Cell Nuclear Antigen Into The Dna Replication Complex

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 21 (1996): 11597-11602

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Fen1 or maturation factor 1 is a 5'-3' exonuclease essential for the degradation of the RNA primer-DNA junctions at the 5' ends of immature Okazaki fragments prior to their ligation into a continuous DNA strand. The gene is also necessary for repair of damaged DNA in yeast. We report that human proliferating-cell nuclear antigen (PCNA) as...更多

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