Two Adaptor Proteins Differentially Modulate The Phosphorylation And Biophysics Of Kv1.3 Ion Channel By Src Kinase.

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 15 (2002): 13268-13280

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The Shaker family K+ channel protein, Kv1.3, is tyrosine phosphorylated by v-Src kinase at Tyr(137) and Tyr(449) to modulate current magnitude and kinetic properties. Despite two proline rich sequences and these phosphotyrosines contained in the carboxyl and amino terminals of the channel, v-Src kinase fails to co-immunoprecipitate with K...更多

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