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Genetic Analysis Of Interactions With Eukaryotic Rrna Identify The Mitoribosome As Target In Aminoglycoside Ototoxicity

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 52 (2008): 20888-20893

Cited: 73|Views27
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Abstract

Aminoglycoside ototoxicity has been related to a surprisingly large number of cellular structures and metabolic pathways. The finding that patients with mutations in mitochondrial rRNA are hypersusceptible to aminoglycoside-induced hearing loss has indicated a possible role for mitochondrial protein synthesis. To study the molecular inter...More

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