A New Synthesis of 2-(2-Hydroxyalkyl)- and 2-(2-Aminoalkyl)-morpholines via 3-Morpholinones

A new pathway for the synthesis of 2-(1-hydroxyalkyl)- and 2-(1-arylaminoalkyl)-morpholines via reaction of alpha-hydroxy- or alpha-amino-alkylation of 3-morpholinones followed by reduction with LiAlH4 of the intermediate compounds into the target substituted morpholines is proposed.