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Chelators At The Cancer Coalface: Desferrioxamine To Triapine And Beyond

CLINICAL CANCER RESEARCH, no. 23 (2006): 6876-6883

Cited: 100|Views22
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Abstract

The importance of iron and copper in cancer biology has been well established. Iron plays a fundamental role in cellular proliferation and copper has been shown to be a significant cofactor for angiogenesis. Early observations with the chelator used for the treatment of iron overload, desferrioxamine, showed that it had promise as an anti...More

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