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Design Of A Potent D-Peptide Hiv-1 Entry Inhibitor With A Strong Barrier To Resistance
JOURNAL OF VIROLOGY, no. 21 (2010): 11235-11244
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摘要
The HIV gp41 N-trimer pocket region is an ideal viral target because it is extracellular, highly conserved, and essential for viral entry. Here, we report on the design of a pocket-specific D-peptide, PIE12-trimer, that is extraordinarily elusive to resistance and characterize its inhibitory and structural properties. D-Peptides (peptides...更多
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