Synthesis of N-[3-(p-aminophenyl)-1-carboxypropyl] derivatives of 1,4,7-triazacyclononane-N,N′-diacetic acid and 1,4,7,10-tetraazacyclododecane-N,N′,N″-triacetic acid: macrocyclic bifunctional chelating agents useful for antibodies labelling
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS(1993)
摘要
Reactions of dicarboxymethylated triazacyclononane (6) and tricarboxymethylated tetraazacyclododecane (7) with ethyl 2-(trifluorosulfonyloxy)-4-phenylbutanoate (3) afforded corresponding N-functionalised cyclic ester derivatives (8) and (12) which served as precursors of above titled macrocyclic bifunctional chelating agents.
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