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The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals

JOURNAL OF CELL BIOLOGY, no. 4 (1992): 831-839

Cited: 104|Views23
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Abstract

We have investigated the role of tyrosine residues in the insulin receptor cytoplasmic juxtamembrane region (Tyr953 and Tyr960) during endocytosis. Analysis of the secondary structure of the juxtamembrane region by the Chou-Fasman algorithms predicts that both the sequences GPLY953 and NPEY960 form tyrosine-containing beta-turns. Similarl...More

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