The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor.
Cancer research, no. 9 (1996): 2059-2065
receptor signal transduction measurements carried out in these cells showed no increases in either total inositol phosphatecyclic amp productiontissues. furthermoreunder estrogen-free conditionsassessed by dna content. our data suggest that although there is a potential for autocrine activity for gnrh in ec as judged by the presence of mr更多(2+)
The presence of a direct extra-pituitary action of gonadotropin-releasing hormone (GnRH) via specific receptors in endometrial cancer (EC) has been suggested as an explanation for the therapeutic effect of GnRH analogue (GnRHa) in recurrent disease. We have sought the expression of the GnRH peptide and functional GnRH receptor (GnRH-R) in...更多
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