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Insights From The X-Ray Crystal Structure Of Coral 8r-Lipoxygenase - Calcium Activation Via A C2-Like Domain And A Structural Basis Of Product Chirality

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 47 (2005): 39545-39552

Cited: 66|Views20
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Abstract

Lipoxygenases (LOXs) catalyze the regio- and stereospecific dioxygenation of polyunsaturated membrane-embedded fatty acids. We report here the 3.2 angstrom resolution structure of 8R-LOX from the Caribbean sea whip coral Plexaura homomalla, a LOX isozyme with calcium dependence and the uncommon R chiral stereospecificity. Structural and s...More

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