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Brca1 Facilitates Stress-Induced Apoptosis In Breast And Ovarian Cancer Cell Lines

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 43 (2000): 33487-33496

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The BRCA1 tumor suppressor gene has previously been implicated in induction of high levels of apoptosis in osteocarcinoma cell lines. Overexpression of BRCA1 was shown to induce an apoptotic signaling pathway involving the c-Jun N-terminal kinase (JNK), but the signaling steps upstream and downstream of JNK were not delineated. To better ...更多

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