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Interactions Between Hepatic Mrp4 And Sult2a As Revealed By The Constitutive Androstane Receptor And Mrp4 Knockout Mice

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 21 (2004): 22250-22257

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pubmed.ncbi.nlm.nih.gov academic.microsoft.com

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knockout miceconstitutive androstane receptor

Abstract

The ABC transporter, Mrp4, transports the sulfated steroid DHEA-s, and sulfated bile acids interact with Mrp4 with high affinity. Hepatic Mrp4 levels are low, but increase under cholestatic conditions. We therefore inferred that up-regulation of Mrp4 during cholestasis is a compensatory mechanism to protect the liver from accumulation of ...More

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