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Inhibitor-Induced Structural Change In The Hcv Ires Domain Iia Rna

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 16 (2010): 7263-7268

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academic.microsoft.com pubmed.ncbi.nlm.nih.gov

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antiviral hepatitis C virus molecular dynamics RNA structure

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Translation of the hepatitis C virus (HCV) RNA is initiated from a highly structured internal ribosomal entry site (IRES) in the 5' untranslated region (5' UTR) of the RNA genome. An important structural feature of the native RNA is an approximately 90 degrees helical bend localized to domain IIa that positions the apical loop of domain I...更多

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