Inhibition Of Ras-Mediated Transformation And Tumorigenesis By Targeting The Downstream E3 Ubiquitin Ligase Seven In Absentia Homologue

Constitutively active RAS small GTpases promote the genesis of human cancers. An important goal in cancer biology is to identify means of countervailing activated RAS signaling to reverse malignant transformation. Oncogenic K-PUS mutations are found in virtually all pancreatic adenocarcinomas, making the RAS pathway an ideal target for th...更多