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Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs).

BIOLOGICAL CHEMISTRY, no. 6 (2006): 817-824

Cited: 100|Views36

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pubmed.ncbi.nlm.nih.gov academic.microsoft.com

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inflammationkallikreinsreceptorsserine proteinasessignal transductionMore(1+)

Abstract

We tested the hypothesis that human tissue kallikreins (hKs) may regulate signal transduction by cleaving and activating proteinase-activated receptors (PARs). We found that hK5, 6 and 14 cleaved PAR N-terminal peptide sequences representing the cleavage/activation motifs of human PAR, and PAR, to yield receptor-activating peptides. hK5, ...More

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