Functional Contacts With A Range Of Splicing Proteins Suggest A Central Role For Brr2p In The Dynamic Control Of The Order Of Events In Spliceosomes Of Saccharomyces Cerevisiae

Mapping of functional protein interactions will help in understanding conformational rearrangements that occur within large complexes like spliceosomes. Because the U5 snRNP plays a central role in pre-mRNA splicing, we undertook exhaustive two-hybrid screening with Brr2p, Prp8p, and other U5 snRNP associated proteins. DExH-box protein Br...更多