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Antibody-Responses To Antigenic Determinants Of Influenza-Virus Hemagglutinin .1. Thymus Dependence Of Antibody-Formation And Thymus Independence Of Immunological Memory

JOURNAL OF EXPERIMENTAL MEDICINE, no. 6 (1974): 1559-1510

Cited: 88|Views29
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Abstract

We have investigated the role of T-lymphocyte cooperation in the humoral response of mice to purified hemagglutinin (HA) 1 extracted from influenza virus. Our results suggest that the T-cell helper effect is required for the secretion of antibody to HA, but not for the development of specific memory in the B-cell lineage. In the accompany...More

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