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Distinguishing The Specificities Of Closely Related Proteases - Role Of P3 In Substrate And Inhibitor Discrimination Between Tissue-Type Plasminogen Activator And Urokinase
JOURNAL OF BIOLOGICAL CHEMISTRY, no. 26 (1997): 16603-16609
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Abstract
Elucidating subtle specificity differences between closely related enzymes is a fundamental challenge for both enzymology and drug design, We have addressed this issue for two intimately related serine proteases, tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), by modifying the technique of substra...More
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