Multiple Endonucleases Function To Repair Covalent Topoisomerase I Complexes In Saccharomyces Cerevisiae

GENETICS, no. 2 (2005): 591-600

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Topoisomerase I plays a vital role in relieving tension on DNA strands generated during replication. However if trapped by camptothecin or other DNA damage, topoisomerase protein complexes may stall replication forks producing DNA double-strand breaks (DSBs). Previous work has demonstrated that two structure-specific nucleases, Rad1 and M...更多

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