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AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells

MOLECULAR CANCER THERAPEUTICS, no. 5 (2009): 1095.0-1105.0

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academic.microsoft.com pubmed.ncbi.nlm.nih.gov

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Abstract

Pancreatic carcinoma is a leading cause of cancer deaths, and recent clinical trials of a number of oncology therapeutics have not substantially improved clinical outcomes. We have evaluated the therapeutic potential of AMG 479, a fully human monoclonal antibody against insulin-like growth factor (IGF) type I receptor (IGF-IR), in two IGF...More

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