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Immunomodulatory effects of CpG oligodeoxynucleotides on established th2 responses.

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, no. 6 (2002): 1260-1269

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CpG oligodeoxynucleotides (CpG ODNs) are known to induce type 1 T-helper-cell (Th1) responses. We have previously demonstrated that CpG ODNs administered during sensitization prevent Th2-mediated eosinophilic airway inflammation in vivo. We also reported that key Th1 cytokines, gamma interferon (IFN-gamma) and interleukin 12 (IL-12), are ...更多

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