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Role Of Glutaredoxin1 And Glutathione In Regulating The Activity Of The Copper-Transporting P-Type Atpases, Atp7a And Atp7b

JOURNAL OF BIOLOGICAL CHEMISTRY, no. 35 (2010): 27111-27121

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The copper-transporting P-type ATPases (Cu-ATPases), ATP7A and ATP7B, are essential for the regulation of intracellular copper homeostasis. In this report we describe new roles for glutathione (GSH) and glutaredoxin1 (GRX1) in Cu homeostasis through their regulation of Cu-ATPase activity. GRX1 is a thiol oxidoreductase that catalyzes the ...更多

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