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A Push-Pull Approach To Maximize Vaccine Efficacy: Abrogating Suppression With An Il-13 Inhibitor While Augmenting Help With Granulocyte/Macrophage Colony-Stimulating Factor And Cd40l

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 20 (2002): 13020-13025

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Although a role for CD4(+) helper cells in CD8(+) cytotoxic T lymphocyte (CTL) induction by vaccines is widely recognized, much less is known about a counterbalancing role of CD4(+) T cells in down-modulating this response, or about ways to optimize vaccine responses through abrogation of this negative regulatory mechanism. Here, we disco...更多

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