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The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype.

Journal of cancer research and clinical oncology, no. 8 (2007): 487-497

Cited: 110|Views27

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Tumor cellsColorectal cancerFiberFermentationColonic damage

Abstract

The short-chain fatty acids (SCFA) are produced via anaerobic bacterial fermentation of dietary fiber within the colonic lumen. Among them, butyrate is thought to protect against colon carcinogenesis. However, few studies analyze the effects of butyrate, and other SCFA, on normal epithelial cells and on epithelial regeneration during dise...More

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