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The Tat Protein Of Human-Immunodeficiency-Virus Type-1, A Growth-Factor For Aids Kaposi-Sarcoma And Cytokine-Activated Vascular Cells, Induces Adhesion Of The Same Cell-Types By Using Integrin Receptors Recognizing The Rgd Amino-Acid-Sequence

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 17 (1993): 7941-7945

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Abstract

Spindle-shaped cells of vascular origin are the probable tumor cells of Kaposi sarcoma (KS). These cells, derived from patients with KS and AIDS, proliferate in response to extracellular Tat protein of human immunodeficiency virus type 1. Normal vascular cells, believed to be the progenitors of AIDS-KS cells, acquire spindle morphology an...More

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