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Antipsychotic Drug-Induced Weight Gain: Development Of An Animal Model

INTERNATIONAL JOURNAL OF OBESITY, no. 6 (2005): 607-614

Cited: 68|Views35

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pubmed.ncbi.nlm.nih.gov academic.microsoft.com

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atypical antipsychotics weight gain hyperphagia

Abstract

OBJECTIVE: Weight gain is a prominent effect of most atypical antipsychotic drugs (AAPDs); yet, the mechanisms are not fully understood and no well-established mouse models exist for investigating the mechanisms. Thus, we developed a mouse model to evaluate the effects of AAPDs on eating, body weight (BW), and body composition.METHODS: Fe...More

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