The discovery of long acting β2-adrenoreceptor agonists

Alan D. Brown,Mark E. Bunnage,Paul A. Glossop,Kim James,Rhys Jones,Charlotte A.L. Lane,Russell A. Lewthwaite,Simon Mantell,Christelle Perros-Huguet, David A. Price,Mike Trevethick,Rob Webster

Bioorganic & Medicinal Chemistry Letters（2007）

引用 49|浏览9

暂无评分

摘要

The design and profile of a series of saligenin containing long acting β2-adrenoreceptor agonists is described. Evaluation of these analogues using a guinea-pig tissue model demonstrates that analogues within this series have significantly longer durations of action than salmeterol and have the potential for a once daily profile in human.

查看译文

关键词

β2,Asthma,COPD,Duration of action,Salmeterol,Formoterol,Bioavailability

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要