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Effects Of Epidermal Growth-Factor And Analogs Of Luteinizing-Hormone-Releasing Hormone And Somatostatin On Phosphorylation And Dephosphorylation Of Tyrosine Residues Of Specific Protein Substrates In Various Tumors

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, no. 5 (1991): 1656-1660

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Analogues of somatostatin (SS) and luteinizing hormone-releasing hormone (LH-RH) activate tyrosine phosphatases in MIA PaCa-2 human pancreatic cancer cell line membranes and inhibit growth. We compared the substrates phosphorylated by epidermal growth factor (EGF) to those dephosphorylated by the SS analogue RC-160 (D-Phe-Cys-Tyr-D-Trp-Ly...更多

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