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The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation.

Cell, no. 6 (2009): 1085-1097

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The scaffold protein Ste5 is required to properly direct signaling through the yeast mating pathway to the mitogen-activated protein kinase (MAPK), Fus3. Scaffolds are thought to function by tethering kinase and substrate in proximity. We find, however, that the previously identified Fus3-binding site on Ste5 is not required for signaling...更多

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